Intranasal curcumin ameliorates airway inflammation and obstruction by regulating MAPKinase activation (p38, Erk and JNK) and prostaglandin D2 release in murine model of asthma
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- 作者：Subhashinia ; Preeti S. Chauhana ; D. Dashb ; B.N. Paulc ; Rashmi Singha ; rashmirs98@rediffmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Prostaglandin D2 ; MAPK ; Extracellular regulated kinases and c-Jun N-terminal kinases ; Eosinophils
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：200-206
- 全文大小：818 K
文摘
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Intranasal curcumin is effective in suppressing airway inflammation and airway Hyperresponsiveness (AHR).
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AHR has been attenuated by phospholipase A2 (sPLA2) activity, and cyclooxygenase -2 (Cox-2) expression thereby suppressed PGD2 release after intranasal curcumin treatment
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Cytokine response (Th2 and Th1 both) has been affected by intranasal curcumin.
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Activation (phosphorylation) of MAPkinases (p38, Erk and JNK) has been attenuated after intranasal curcumin treatment.