Intranasal curcumin is effective in suppressing airway inflammation and airway Hyperresponsiveness (AHR).
AHR has been attenuated by phospholipase A2 (sPLA2) activity, and cyclooxygenase -2 (Cox-2) expression thereby suppressed PGD2 release after intranasal curcumin treatment
Cytokine response (Th2 and Th1 both) has been affected by intranasal curcumin.
Activation (phosphorylation) of MAPkinases (p38, Erk and JNK) has been attenuated after intranasal curcumin treatment.