Plasma levels of atrial and brain natriuretic peptides in apparently healthy subjects: Effects of sex, age, and hemoglobin concentration

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• 关键词：Healthy subjects ; ANP ; BNP ; Sex ; Aging ; Hemoglobin
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：599-604
• 全文大小：698 K
• 卷排序：228

文摘

To examine whether the use of one value of natriuretic peptides to define “normal” is appropriate in all individuals, and to assess the influence of sex, age, and other variables on atrial and brain natriuretic peptides (ANP, BNP) levels.Methods and resultsA total of 1375 apparently healthy people (women:155, men:1220), aged 18–70 years were enrolled. Both ANP and BNP levels were higher in women than in men (ANP: 12.50 ± 6.82 pg/mL vs 8.18 ± 4.19 pg/mL; BNP: 9.85 ± 7.63 pg/mL vs 7.03 ± 6.97 pg/mL). The subjects were divided into three age groups: group I, 18–30 years; group II, 30–50 years; group III, 50–70 years. First, the influence of age on ANP and BNP levels was examined. In women, both ANP and BNP levels were higher in groups II and III than those in group I. In men, ANP and BNP levels increased with age. Second, sex differences in ANP and BNP levels due to age were examined. ANP level was higher in women than that in men in all age groups. BNP level was higher in women than that in men in groups I and II. Multivariate analysis indicated that both ANP and BNP levels were influenced by age, hemoglobin level, and platelet counts.ConclusionBecause ANP and BNP levels in healthy subjects are influenced by sex, age, and hemoglobin levels, the use of a single value to define “normal” in all individuals is not appropriate.