Can 鈥榚xtrafine鈥?dry powder aerosols improve lung deposition?
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- 作者：Anne H. de Boer ; a.h.de.boer@rug.nl" class="auth_mail" title="E-mail the corresponding author ; Doetie Gjaltema ; Paul Hagedoorn ; Henderik W. Frijlink
- 关键词：Dry powder inhaler ; Extrafine aerosol ; ICS ; Lung deposition ; Small airway targeting ; Submicron particles
- 刊名：European Journal of Pharmaceutics and Biopharmaceutics
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：96
- 期：Complete
- 页码：143-151
- 全文大小：1951 K
文摘
There is increasing interest in the use of so-called ‘extrafine’ aerosols to target the small airways in the management of asthma and COPD. Using previously presented deposition data, we assessed whether submicron (<1 渭m) particles can improve central and deep lung deposition. Our data show instead that particles in the range 1–3 渭m are much more relevant in this respect. Based on this finding the Symbicort Turbuhaler, Seretide Diskus, Rolenium Elpenhaler and Foster (Fostair) NEXThaler ICS/LABA combination DPIs were tested in vitro as a function of the pressure drop (2, 4 and 6 kPa) across the inhaler. Obtained fine particle fractions (FPFs) <5 渭m (as percent of label claim) were divided into subfractions <1, 1–3 and 3–5 渭m. Differences of up to a factor of 4 were found between the best (Turbuhaler) and worst performing DPI (Elpenhaler), particularly for the FPF in the size range 1–3 渭m. The NEXThaler, described as delivering ‘extrafine’ particles, did not appear to be superior in this size range. The marked differences in amount and size distribution of the aerosols between the devices in this study must cause significant differences in the total lung dose and drug distribution over the airways.