Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart
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- 作者：Anna Stepanovaa ; b ; Yevgeniya Shuruborc ; Federica Valsecchid ; Giovanni Manfredid ; Alexander Galkina ; d ; a.galkin@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author ; alg2057@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：A/D ; active/de-active transition ; DDM ; n-Dodecyl β-d-maltoside ; FAD ; flavin adenine dinucleotide ; GOT1 ; glutamic/oxaloacetate transaminase ; Type 1 ; HAR ; hexaammineruthenium ; I/R ; ischemia/reperfusion ; OAA ; oxaloacetate ; Q1 ; 2 ; 3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1 ; 4-benzoquinone ; RET ; reverse electron transfer ; SDH ; succinate dehydrogenase ; SET medium ; sucrose/EDTA/Tris medium ; SMP ; submitochondrial particles ; TCA ; tricarboxylic acid cycle
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1857
- 期：9
- 页码：1561-1568
- 全文大小：712 K
文摘
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Complex II in mitochondrial membranes is inhibited by tightly-bound oxaloacetate.
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Oxaloacetate binds to the heart enzyme during isolation.
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In brain a large fraction of Complex II is present in oxaloacetate-bound form.
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Short-time tissue ischemia does not affect the content of the free Complex II in brain.