Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I
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- 作者：Judy Hirsta ; jh@mrc-mbu.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Maxie M. Roesslerb ; m.roessler@qmul.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：CW ; continuous wave ; ESEEM ; electron spin echo envelope modulation ; EPR ; electron paramagnetic resonance ; FeS ; iron&ndash ; sulfur ; HYSCORE ; hyperfine sub-level correlation ; SMP ; submitochondrial particle ; SQ ; semiquinone
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1857
- 期：7
- 页码：872-883
- 全文大小：1425 K
文摘
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Current knowledge of the redox reactions catalyzed by complex I is reviewed.
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Possible quinone reduction pathways are presented.
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The presence and number of semiquinone intermediates are deliberated.
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The involvement of cluster N2/semiquinones in coupled proton transfer is discussed.
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Evidence for reactive oxygen species production by semiquinones is examined.