Oxidation of NADH and ROS production by respiratory complex I
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- 作者：Andrei D. Vinogradov ; adv@biochem.bio.msu.su" class="auth_mail" title="E-mail the corresponding author ; Vera G. Grivennikova
- 关键词：APAD+ ; ; 3-acetylpyridine adenine dinucleotide ; Ferri ; ferricyanide ; FMN ; flavin mononucleotide ; HAR ; hexaammineruthenium(III) ; Qn ; 2 ; 3-dimethoxy ; 5-methyl ; 6-(n)isoprenyl ; 1 ; 4-benzoquinone ; ROS ; reactive oxygen species ; SMP ; submitochondrial particles ; O2&bull ; ̅ ; superoxide anion ; SOD ; superoxide dismutase ; p.m.f. ; proton-motive force (transmembrane gradient of electrochemical activity of H+ ; Δμ&tilde ; Η+)
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1857
- 期：7
- 页码：863-871
- 全文大小：587 K
文摘
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Steady-state reactions catalyzed by respiratory complex I are discussed.
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Unexplained observations on the proton-pumping activity of the enzyme are pointed out.
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Oxygen reduction to superoxide and(or) hydrogen peroxide by complex I is described.
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Physiological significance of mitochondrial ROS production is critically evaluated.