Infection and preterm birth

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• 作者：Hugh C.G. Nadeau ; ^{hnadeau@uabmc.edu" class="auth_mail" title="E-mail the corresponding author} ; Akila Subramaniam ; William W. Andrews
• 关键词：Premature birth ; Vaginosis ; Sexually transmitted diseases ; Reproductive tract infections ; Microbiome ; Metabolome
• 刊名：Seminars in Fetal and Neonatal Medicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：21
• 期：2
• 页码：100-105
• 全文大小：463 K

文摘

Preterm birth (PTB) remains a primary cause of neonatal morbidity and mortality. The purpose of this article is to outline the association between infection and PTB. We performed a search of the PubMed database for relevant scientific work published in English from 1995 to July 2015. Whereas there is substantial evidence regarding infection as a strong risk factor for preterm birth, the role of specific bacterial and viral infections is not totally conclusive. Newer high-dimensional biological technologies such as microbiomics and metabolomics offer hope to identify the causative pathogens. In addition, strategies have been developed to reduce PTB.