Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) enhances IL-10 production through the activation of Bruton's tyrosine kinase and STAT3

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• 作者：Ryan Incrocci^a ; Levi Barse^b ; Amanda Stone^a ; Sai Vagvala^a ; Michael Montesano^a ; Vijay Subramaniam^b ; Michelle Swanson-Mungerson^a ; ^{mswans@midwestern.edu}
• 关键词：B cell ; Epstein-Barr virus ; Latent Membrane Protein 2A ; Interleukin-10 ; Bruton's tyrosine kinase (BTK) ; Signal Transducer and Activator of Transcription 3 (STAT3)
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：96-102
• 全文大小：1076 K
• 卷排序：500

文摘

LMP2A stimulates the PI3K-dependent activation of BTK to phosphorylate STAT3. The addition of the STAT3 inhibitor, Stattic, blocks the LMP2A-mediated increase in STAT3 phosphorylation and IL-10 production in B cell lymphomas. The BTK inhibitor, Ibrutinib, decreases the LMP2A-dependent increase in IL-10, which may provide a novel therapy for EBV-associated lymphomas.