HSP70/90 and Survivin expressions in primary Retinoblastoma tissues are reported.
Treatment of shepherdin, targeting HSP90/Survivin has anti-cancer effect in RB.
Shepherdin treatment causes molecular shuffling (Bax, Bim, Bcl2, caspase-9, MMPs).
Negligible toxicity in normal cells treated with shepherdin.
Targeting HSP90/Survivin may be a promising adjuvant therapy for RB implicated.