A comparative study of glycodelin concentrations in uterine flushings in women with subseptate uteri, history of unexplained recurrent miscarriage and healthy controls

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• 作者：R. Salim ; J. Miel ; M. Savvas ; C. Lee ; D. Jurkovic
• 关键词：Subseptate uterus ; Recurrent miscarriage ; Glycodelin
• 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
• 出版年：2007
• 出版时间：July 2007
• 年：2007
• 卷：133
• 期：1
• 页码：76-80
• 全文大小：152 K

文摘

To compare the concentration of glycodelin in uterine flushing at the implantation window obtained from women with subseptate uteri, women with a history of recurrent first trimester miscarriage and fertile controls.

Study design

Glycodelin concentration was assessed using Enzyme Linked Immunohistochemistry (ELISA) at The Early Pregnancy & Gynaecology Assessment Unit, King's College Hospital, London, England. Eight women with a subseptate uterus, 20 women with a history of unexplained recurrent first trimester miscarriage and 16 fertile controls had uterine cavity flushing, for glycodelin concentration, done 7 days after the luteinising hormone surge.

Results

Glycodelin concentrations in uterine flushing obtained from women with subseptate uteri (n =8) (median 32.9 ng/ml, range 17.1–52.4 ng/ml) and recurrent miscarriage (n =20) (median 26.8 ng/ml, range 9.7–78.5 ng/ml) were significantly lower than in the control group (n = 16) (median 67.7 ng/ml, range 59.0–77.6 ng/ml) (χ² = 19.565, p < 0.001).

Conclusion

Peri-implantation levels of glycodelin are lower in women at high risk of early pregnancy failure.