Utilization of DmbNHNH₂ in the synthesis of amino-substituted 4-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenols

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• 作者：Eva Schü ; tznerová ; ^a ; Igor Popa^b ; Vladimí ; r Kry&scaron ; tof^c ; Hiroyuki Koshino^d ; Zden¨§k Trá ; vní ; ?ek^b ; Pavel Hradil^a ; Petr Canka?^a ; ^{cankar@orgchem.upol.cz}
• 关键词：(2 ; 4-Dimethoxybenzyl)hydrazine ; Dmb-protecting group ; Nitrogen heterocycles ; Regioselective acylation ; CDK inhibitors
• 刊名：Tetrahedron
• 出版年：2012
• 出版时间：27 May, 2012
• 年：2012
• 卷：68
• 期：21
• 页码：3996-4002
• 全文大小：504 K

文摘

(2,4-Dimethoxybenzyl)hydrazine (DmbNHNH₂) was utilized in the synthesis of Dmb-protected 4-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenols. This unambiguous protection of the pyrazole endocyclic nitrogen atom enabled the preparation of amino-substituted 4-((3,5-diamino-1H-pyrazol-4yl)diazenyl)phenols that were inaccessible through direct substitution. The Boc group could be selectively cleaved in the presence of the Dmb group.