Meis/UNC-62 isoform dependent regulation of CoupTF-II/UNC-55 and GABAergic motor neuron subtype differentiation

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• 作者：Richard F. Campbell ; Walter W. Walthall ; ^{wwalthall@gsu.edu}
• 关键词：Gene regulatory networks ; Subtype determining transcription factors ; Isoform specific regulation ; Motor neurons
• 刊名：Developmental Biology
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：419
• 期：2
• 页码：250-261
• 全文大小：2956 K
• 卷排序：419

文摘

CoupTFII/UNC-55 differentiates specific GABAergic motor neuron subtypes. The unc-55 promoter contains distinct regions required for expression/repression. Different Meis/UNC-62 isoforms act through specific regions of the unc-55 promoter. UNC-62 isoforms differentially regulate the mRNA and protein expression of UNC-55