Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly
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- 作者：Mayelí ; n Domí ; ngueza ; mdominguezg@idibell.cat" class="auth_mail" title="E-mail the corresponding author ; Eliandre de Oliveirab ; eoliveira@pcb.ub.es" class="auth_mail" title="E-mail the corresponding author ; Marí ; a Antonia Odenab ; maodena@pcb.ub.es" class="auth_mail" title="E-mail the corresponding author ; Manuel Porteroc ; manuel.portero@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Reinald Pamplonac ; reinald.pamplona@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Isidro Ferrera ; d ; e ; 8082ifa@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACO2 ; aconitate hydratase ; ATP5A1 ; ATP synthase subunit alpha ; AD ; Alzheimer's disease ; BASP1 ; brain acid soluble protein 1 ; BLVRB ; NADPH-flavin reductase ; CA1 ; carbonic anhydrase 1 ; CG ; cingulate gyrus ; CKB ; creatine kinase B-type ; CRYAB ; alpha-crystallin B chain ; DHA ; docosahexaenoic acid ; DLD ; dihydrolipoyl dehydrogenase ; DPYSL2 ; dihydropyrimidinase-related protein 2 ; ENO1 ; alpha-enolase ; FC ; frontal cortex ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GFAP ; glial fibrillary acidic protei
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：1-15
- 全文大小：4292 K
文摘
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Region-dependent brain protein lipoxidation occurs at middle age and increases in old age.
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Proteins involved in energy metabolism, cytoskeleton, proteostasis, neurotransmission and O2/CO2, and heme metabolism are the main targets.
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Sub-cellular localization, secondary structure and external exposition of certain amino acids are contributory factors in protein vulnerability.
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Non-identified oligomers correlate with protein neuroketal adduction.