A novel subunit of axonemal dynein conserved among lower and higher eukaryotes

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• 作者：Ryosuke Yamamoto ; Haru-aki Yanagisawa ; Toshiki Yagi ; Ritsu Kamiya
• 关键词：Inner arm dynein ; Light chain ; p28 ; Actin ; Chlamydomonas
• 刊名：FEBS Letters
• 出版年：2006
• 出版时间：27 November 2006
• 年：2006
• 卷：580
• 期：27
• 页码：6357-6360
• 全文大小：505 K

文摘

To elucidate the subunit composition of axonemal inner-arm dynein, we examined a 38 kDa protein (p38) co-purified with a Chlamydomonas inner arm subspecies, dynein d. We found it is a novel protein conserved among a variety of organisms with motile cilia and flagella. Immunoprecipitation using specific antibody verified its association with a heavy chain, actin and a previously identified light chain (p28). Unexpectedly, mutant axonemes lacking dynein d and other dyneins retained reduced amounts of p38. This finding suggests that p38 is involved in the docking of dynein d to specific loci.