Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase
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- 作者：Toshifumi Yamamotoa ; yamamoto@yokohama-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Tomomi Nakayamaa ; Junji Yamaguchia ; Maaya Matsuzawaa ; Masayoshi Mishinab ; Kazutaka Ikedac ; Hideko Yamamotoc
- 关键词：CPP ; 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid ; GluN2D-KO ; GluN2D knockout ; NADPH-d ; nicotinamide adenine dinucleotide hydrogen phosphate diaphorase ; NBT ; nitroblue tetrazolium ; NMDAR ; NMDA receptor ; nNOS ; neuronal nitric oxide synthase ; NO ; nitric oxide ; PB ; phosphate buffer ; PBS ; phosphate buffered saline ; PCP ; phencyclidine ; WT ; wild type
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：610
- 期：Complete
- 页码：48-53
- 全文大小：1481 K
文摘
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GluN2D subunit is essential for ketamine-induced behavioral sensitization.
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Ketamine rapidly increases neuronal NOS activity in the striatum and frontal cortex.
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Fronto-striatal pathway is important for ketamine-induced behavioral sensitization.