Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus
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- 作者：Grace Francea ; Diego Ferná ; ndez-Ferná ; ndeza ; Erica S. Burnella ; Mark W. Irvinea ; Daniel T. Monaghanc ; David E. Janea ; Zuner A. Bortolottoa ; Graham L. Collingridgea ; d ; Arturas Volianskisb ; e ; A.Volianskis@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author ; A.Volianskis@qmul.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Long-term depression ; LTD ; Short-term potentiation ; STP ; Long-term potentiation ; LTP ; NMDA receptors
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：76-83
- 全文大小：1546 K
文摘
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Inhibition of GluN2Bs in P14 is sufficient for blockade of NMDAR-LTD.
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GluN2A and GluN2D subunits are not required for the induction of LTD.
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Induction of STP involves GluN2B and GluN2D subunits.
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Induction of LTP depends on GluN2A/2B triheteromers.