A new fluorogenic probe for solution and intra-cellular sensing of trivalent cations in model human cells
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- 作者：Soham Samanta ; Sudeep Goswami ; Aiyagari Ramesh ; Gopal Das
- 关键词：Trivalent ion sensor ; Fluorescence turn-on ; Proton-induced fluorescence change ; Cell imaging
- 刊名：Sensors and Actuators B: Chemical
- 出版年：April, 2014
- 年：2014
- 卷：194
- 期：Complete
- 页码：120-126
- 全文大小：2279 K
文摘
A new imidazole functionalized anthracene based Schiff base (L) was synthesized and it's selective colorimetric as well as fluorescence responses to trivalent metal cations (Al3+, Fe3+ and Cr3+) over a variety of divalent and monovalent metal cations in 1:1 methanol-water mixed solvent and in live HeLa cells were demonstrated. These selective colorimetric and fluorescence responses were explained as a consequence of protonation of L, where the lower Ksp values of M3+ (Al3+, Fe3+ and Cr3+) facilitated the generation of H+ through hydrolysis. This fluorogenic behavior of the ligand L was further confirmed by theoretical calculations.