Relation of Systemic Blood Pressure to Sudden Cardiac Death

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• 作者：Jari Antero Laukkanen ; J. Richard Jennings ; Jussi Kauhanen ; Timo Heikki M?kikallio ; Kimmo Ronkainen ; Sudhir Kurl
• 刊名：The American Journal of Cardiology
• 出版年：2012
• 出版时间：1 August, 2012
• 年：2012
• 卷：110
• 期：3
• 页码：378-382
• 全文大小：290 K

文摘

The role of systolic blood pressure (SBP) as an independent risk factor for sudden cardiac death (SCD) is not well defined in a general population. Thus, we assessed the association between BP at rest and risk of SCD. BP and other risk factors were measured in a representative population-based sample of 2,666 Finnish men (42 to 61 years of age). During an average follow-up period of 18.9 years (interquartile range 17.9 to 22.6), 213 SCDs occurred. Each increment 10-mm Hg of SBP at rest was associated with an increased risk of SCD (relative hazard 1.15, 95 % confidence interval 1.07 to 1.25, p <0.001) after adjustment for age, alcohol consumption, cigarette smoking, serum low-density lipoprotein cholesterol, type 2 diabetes, body mass index, left ventricular hypertrophy, previous myocardial infarction, family history of coronary heart disease, and use of antihypertensive medications. Men with increased SBP of >145 mm Hg had a 2.04-fold (95 % confidence interval 1.23 to 2.52, p = 0.003) adjusted risk for SCD compared to those with SBP <123 mm Hg. In conclusion, this study emphasizes the importance of the definition of SBP at rest because it provides a valuable prognostic measurement for SCD.