Direct introduction of R-SO2F moieties into proteins and protein-polymer conjugation using SuFEx chemistry
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- 作者：Shaohua Lia ; Devora Cohen-Karnia ; Laura T. Beringera ; Changgong Wub ; Ethan Kallicka ; c ; Howard Edingtonc ; Michael J. Passineaub ; Saadyah Avericka ; saverick@wpahs.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bioconjugation ; SuFEx ; Click chemistry
- 刊名：Polymer
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：7-12
- 全文大小：982 K
文摘
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Sulfuryl fluoride gas was reacted with bovine serum albumin to yield BSA-SO2F.
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Bioconjugates could be formed through a SuFEx reaction between BSA-SO2F and PEG-OTBDMS.
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SuFEx chemistry was used to self-condense BSA-SO2F into biocompatible hydrogels.