Vitronectin promotes the progress of the initial differentiation stage in cerebellar granule cells
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- 作者：Kei Hashimoto ; Fumi Sakane ; Natsumi Ikeda ; Ayumi Akiyama ; Miyaka Sugahara ; Yasunori Miyamoto ; miyamoto.yasunori@ocha.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：VN ; vitronectin ; CGC ; cerebellar granule cell ; CGCP ; cerebellar granule cell precursor ; WT ; wild- type ; VNKO ; VN knockout ; iEGL ; inner external granule layer ; IGL ; internal granule layer ; P ; postnatal day ; EGL ; external granule layer ; TAG1 ; transient axonal glycoprotein 1 ; ML ; molecular layer ; PcL ; Purkinje cell layer ; oEGL ; outer external granule layer ; LN ; laminin ; Shh ; Sonic hedgehog ; CREB ; cyclic-AMP responsive element binding protein ; PBS ; phosphate-buffered saline ; BrdU ; bromodeoxyuridine
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：76-85
- 全文大小：2124 K
文摘
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In VNKO mice, the number of CGCs in the IGL is reduced at P8.
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VN does not affect the proliferation of CGCPs in vivo.
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Loss of VN inhibits the progress of the initial differentiation stage of CGCPs.
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Migration of CGCPs from the EGL to the IGL is suppressed in VNKO mice.