Overview of Nucleotide Sugar Transporter Gene Family Functions Across Multiple Species
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- 作者：Ariel Orellana1 ; 2 ; aorellana@unab.cl" class="auth_mail" title="E-mail the corresponding author ; Carol Moraga1 ; caritolmoraga@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Macarena Araya1 ; macarena.araya.tapia@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Adrian Moreno1 ; 2 ; amovil@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：NST ; nucleotide sugar transporter ; PAPS ; 3&prime ; -phosphoadenosine 5&prime ; -phosphosulfate ; CMP-SA ; CMP-sialic acid
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：14 August 2016
- 年：2016
- 卷：428
- 期：16
- 页码：3150-3165
- 全文大小：581 K
文摘
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NST activity and amino acid sequence are not associated.
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Phylogenetic analyses allow for the association of NSTs sequence and activity.
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GDP-sugars, PAPS, CMP-SA, and sugar phosphates require specific subsets of NSTs.
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UDP-sugars are transport by NSTs that does not share amino acid sequence similarity.
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Evolution drives NSTs substrate affinity from UDP-sugars to other nucleotide sugars.