Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species
详细信息 查看全文
- 作者：Yuuna Kamiya ; Satoru Mizuno ; Suguru Komenoi ; Hiromichi Sakai ; Fumio Sakane ; sakane@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：cPKC ; conventional protein kinase C ; DG ; diacylglycerol ; DGK ; diacylglycerol kinase ; MBP ; myelin basic protein fragment 4-14 ; nPKC ; novel protein kinase C ; PKC ; protein kinase C ; TPA ; 12-O-Tetradecanoylphorbol-13-acetate
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：7
- 期：Complete
- 页码：361-366
- 全文大小：1003 K
文摘
- •
We comprehensively analyzed activation of c/nPKC isozymes by different DG species.
- •
c/nPKCs have different sensitivities and dependences on DG.
- •
c/nPKCs have a distinct preference for different fatty acid-containing DG species.
- •
This differential regulation would be important for PKCs' physiological functions.