MnTE-2-PyP combined with radiation further inhibits growth and metastasis of human prostate cancer cells.
MnTE-2-PyP inhibits p300 HAT activity and alters p300 transcriptional complex binding to DNA.
Specifically, MnTE-2-PyP reduces histone acetylation of the promoter of PAI-1, which is regulated by HIF-1, CREB and p300.
This is the first study to show that MnTE-2-PyP can epigenetically regulate gene expression.