Characteristics and risk factors of hospital acquired - Methicillin-resistant Staphylococcus aureus (HA-MRSA) infection of pediatric patients in a tertiary care hospital in Riyadh, Saudi Arabia

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• 作者：Khalid Alrabiah ; ¹ ; ^{kaaksa@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sulaiman Al Alola ; Esam Al Banyan ; Mohammad Al Shaalan ; Sameera Al Johani
• 关键词：HA-MRSA ; Pediatric ; Epidemiology
• 刊名：International Journal of Pediatrics and Adolescent Medicine
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：3
• 期：2
• 页码：71-77
• 全文大小：1285 K

文摘

The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infections has been steadily increasing. These infections are considered to be either hospital-acquired MRSA (HA-MRSA) or community-acquired MRSA (CA-MRSA). Children are at higher risk of infection than adults. HA-MRSA has been reported to have more serious outcomes than CA-MRSA. However, there are not enough studies in Saudi Arabia to study the characteristics of HA-MRSA in children. We aim to describe the characteristics of HA-MRSA infection, including risk factors, culture site, clinical manifestations, complications, and outcomes among pediatric patients in a tertiary care hospital in Riyadh, Saudi Arabia.

Design and settings

This is a retrospective chart review study. It was conducted in King Abdulaziz medical city in Riyadh.

Patients and methods

The study included all patients 14 years of age or younger who were culture-positive from any site in the body during the period from January 1, 2009 to December 31, 2011. The time of culture compared to admission time was used to differentiate between CA-MRSA (within 72 h of admission) and HA-MRSA (more than 72 h after admission). The final sample size was 39 patients.

Results

We found HA-MRSA to be more common in males and those with risk factors such as previous surgery and previous hospitalization. Patients had a high Pediatric intensive care unit (PICU) admission rate and were commonly septic with positive blood cultures. Seventy-four percent of patients fully recovered, 10% recovered with complications and 15% died.

Conclusion

HA-MRSA is an infection that can cause serious complications and a high rate of PICU admissions. Clinical manifestations such as shock are associated with higher mortality and morbidity rates. Special care should be given to those admitted to PICU, as they have high rates of mortality and morbidity.