Determination of the binding properties of the uremic toxin phenylacetic acid to human serum albumin
详细信息 查看全文
- 作者：Juliana F. Saldanha
- 关键词：Phenylacetic acid ; Uremic toxin ; Human serum albumin ; Protein binding ; Chronic kidney disease ; Uremic syndrome
- 刊名：Biochimie
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：53-58
- 全文大小：578 K
文摘
- •
- <p id="p0010">Phenylacetic acid (PAA) is an uremic toxins that accumulates in patients with chronic kidney disease.p>
- •
- <p id="p0015">Human serum albumin (HSA) is a protein carrier for PAA.p>
- •
- <p id="p0020">There is one single high-affinity binding site for PAA on HSA.p>
- •
- <p id="p0025">PAA does not compete with other hydrophobic uremic toxins such as p-cresyl-sulfate or indoxyl sulfate for binding to HSA.p>