Conversion of methyl ketones and methyl sulfones into α-deutero-α,α-difluoromethyl ketones and α-deutero-α,α-difluoromethyl sulfones in three synthetic steps

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• 作者：Munia F. Sowaileh^a ; Changho Han^b ; ¹ ; Robert A. Hazlitt^a ; Eun Hoo Kim^b ; ² ; Jinu P. John^b ; ³ ; David A. Colby^a ; ^{dacolby@olemiss.edu}
• 关键词：Fluorine ; Enolate ; Deuteration ; Ketones ; Base
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：58
• 期：5
• 页码：396-400
• 全文大小：3149 K
• 卷排序：58

文摘

Deuterodifluoromethyl ketones and sulfones are prepared in three synthetic steps. High levels of deuterium on the “CF2D” group are observed. Over- and under-fluorinated by-products are not isolated using this process.