Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506
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- 作者：C.R. Overka ; E. Rockensteina ; J. Florioa ; Q. Chenga ; E. Masliaha ; b ; emasliah@UCSD.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：3R ; triple-repeat ; AD ; Alzheimer&rsquo ; s disease ; APP ; amyloid precursor protein ; AUC ; area under the curve ; Aβ ; amyloid β ; F ; fluorescent signal ; FOV ; field of view ; h ; human ; ISI ; interstimulus intervals ; F ; fluorescent signal ; m ; murine ; NFT ; neurofibrillary tangle ; OGB ; Oregon Green 488 BAPTA-1 AM ; PD ; Parkinson&rsquo ; s disease ; PiD ; Pick&rsquo ; s disease ; ROC ; Receiver Operator Characteristic ; SPR ; statistical pattern recognition ; SR101 ; sulforhodamine 101 ; tau ; microtubule-associated protei
- 刊名：Neuroscience
- 出版年：2015
- 出版时间：3 December 2015
- 年：2015
- 卷：310
- 期：Complete
- 页码：549-560
- 全文大小：3186 K
文摘
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In vivo two-photon microscopy data collected from WT α-syn, E57K α-syn, APP, 3R-Tau and Non-tg mice.
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Calcium transients AUCs were significantly increased for WT α-syn, E57K α-syn and APP mice with 1-Hz stimulus.
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Two-photon microscopy data coupled to statistical classifiers create a bioassay to identify different mouse types.
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Our statistical classifier bioassay confirmed that FK506 normalized WT α-syn calcium transients.