Involvement of chondroitin 6-sulfation in temporal lobe epilepsy
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- 作者：Noriko Yutsudo ; Hiroshi Kitagawa ; kitagawa@kobepharma-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNS ; central nervous system ; C4ST ; chondroitin 4-O-sulfotransferase ; C6ST ; chondroitin 6-O-sulfotransferase ; CS ; chondroitin sulfate ; TG ; transgenic ; PG ; proteoglycan ; GABA ; γ-aminobutyric acid ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; Narp ; neuronal activity-regulated pentraxin ; Otx2 ; orthodenticle homeobox 2 ; PNNs ; perineuronal nets ; PV cells ; parvalbumin-expressing inhibitory neurons ; Sema3A ; semaphorin3A ; WFA ; Wisteria floribunda agglutinin
- 刊名：Experimental Neurology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：274
- 期：part_PB
- 页码：126-133
- 全文大小：1632 K
文摘
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160">Kainic acid (KA) treatment increases chondroitin 6-sulfation in the cerebral cortex.
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165">KA treatment decreases WFA-positive perineuronal nets in the cerebral cortex.
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170">Mice overexpressing chondroitin 6-sulfated chains are more susceptible to seizures.
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175">Chondroitin 6-sulfated chains have an important role in epilepsy.