Synthesis and molecular modelling studies of novel sulphonamide derivatives as dengue virus 2 protease inhibitors
详细信息 查看全文
- 作者：Ajay Kumar Timiria ; Subasri Selvarasub ; Manish Kesherwanib ; Vishwanathan Vijayanb ; Barij Nayan Sinhaa ; Velmurugan Devadasanb ; Venkatesan Jayaprakasha ; venkatesanj@bitmesra.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antiviral ; Dengue ; NS2B&ndash ; NS3 protease ; Phthalimide ; Sulphonamides ; Molecular docking ; Molecular interactions
- 刊名：Bioorganic Chemistry
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：62
- 期：Complete
- 页码：74-82
- 全文大小：1269 K
文摘
- •
HTVS was performed against DENV2 NS2B/NS3 protease.
- •
A series of sulphonamide derivatives were synthesized and screened for DENV2 protease.
- •
Compound 16 and compound 19 showed activity at lower 渭M concentration.
- •
Molecular modeling studies were done to understand interaction at molecular level.
- •
X-ray crystal structure of compound 16 was determined.