CAT-1 as a novel CAM stabilizes endothelial integrity and mediates the protective actions of l-Arg via a NO-independent mechanism
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- 作者：Lu Guoa ; Shuang Tiana ; Yuguo Chenb ; Yun Maoa ; Sumei Cuib ; Aihua Huc ; Jianliang Zhangd ; Shen-Ling Xiad ; Yunchao Sud ; Jie Due ; Edward R. Blockd ; Xing Li Wanga ; f ; xingliwang@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhaoqiang Cuia ; zcui@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CAT-1 ; Cell adhesion molecule ; Vascular permeability ; l-arginine paradox ; trans-stimulation
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：87
- 期：Complete
- 页码：180-191
- 全文大小：2189 K
文摘
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Cationic amino acid transporter-1 (CAT-1) is a novel cell adhesion molecule (CAM).
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Extracellular l-Arg exposure abates the EC junction disassembly of CAT-1.
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CAT-1 mediates the vascular protection of l-Arg via a NO-independent mechanism.