Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

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• 作者：Katherine N. Choe¹ ; ² ; George-Lucian Moldovan¹ ; ³ ; ^{glm29@psu.edu}
• 关键词：PCNA ; DNA replication ; DNA repair ; genomic stability ; translesion synthesis ; ubiquitin ; SUMO ; chromatin
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：380-392
• 全文大小：854 K
• 卷排序：65

文摘

Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.