The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis: a systematic review and meta-analysis

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• 作者：Jun Ju ; MD^a ; ^b ; ^&lowast ; ; Yun Li ; MD^a ; ^&lowast ; ; Juan Chai ; MD^c ; Chao Ma ; PhD ; MD^a ; Qianwei Ni ; PhD^a ; Zhiyuan Shen^a ; Jianhua Wei ; MD ; PhD^a ; Moyi Sun ; MD ; PhD^a ; ^{Moyisun@163.com" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：122
• 期：6
• 页码：691-701
• 全文大小：772 K

文摘

We performed a systematic review to assess the prognostic value of perineural invasion (PNI) for patients with head and neck adenoid cystic carcinoma.

Study Design

A literature search of MEDLINE and EMBASE was used to identify relevant literature up to December 2015. The primary outcomes of interest were overall survival, disease-free survival, and locoregional control. Study information and hazard ratios (HRs) were extracted, and HRs were pooled using the Mantel-Haenszel fixed-effects model and the DerSimonian and Laird random-effects model according to heterogeneity.

Results

Twenty-two studies and 1332 patients were included in this study. The PNI ratio was 43.2%. PNI was at increasing risk for overall survival (HR = 2.98; 95% confidence interval [CI] 2.00-4.46), disease-free survival (HR = 1.88; 95% CI, 1.42-2.49), and locoregional control (HR = 2.15; 95% CI, 1.48-3.13) with statistical significance.

Conclusions

PNI is an independent factor for poor prognosis in patients with head and neck adenoid cystic carcinoma. Moreover, PNI poses a significantly higher threat to male patients and younger patients.