A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells
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- 作者：Wenzhao Li ; Junji Itou ; junji-itou@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Sunao Tanaka ; Tomomi Nishimura ; Fumiaki Sato ; Masakazu Toi
- 关键词：Basal-like breast cancer ; Cell growth ; IL-6 ; NKX6.1 ; Transcription factor
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：343
- 期：2
- 页码：177-189
- 全文大小：3980 K
文摘
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NKX6.1 is up-regulated in basal-like breast cancer.
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NKX6.1 directly promotes IL6 expression.
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The NKX6.1-IL-6 network positively regulates cell growth.
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NKX6.1 is involved in tumor formation.