Analysis of pancreatic polypeptide cDNA from the house musk shrew, Suncus murinus, suggests a phylogenetically closer relationship with humans than for other small laboratory animal species

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• 作者：Hoyle ; C.H.V. ; Hill ; J. ; Sanger ; G.J. ; Andrews ; P.L.R.
• 关键词：Suncus ; Pancreatic polypeptide ; Evolution ; Primary sequence
• 刊名：Regulatory Peptides
• 出版年：2003
• 出版时间：July 15, 2003
• 年：2003
• 卷：114
• 期：2-3
• 页码：137-144
• 全文大小：178 K

文摘

Pancreatic polypeptide was isolated and sequenced from endocrine cells of the pancreas from an insectivore, the house musk shrew, Suncus murinus. The primary sequence was APLEPAYPGD(10)NATPEQMAQY(20)AAELRKYINM(30)VTRPRYamide. This is the first polypeptide hormone to be characterised from this species and is typical of the primary sequences of pancreatic polypeptide of other animals, being a C-terminal-amidated peptide with 36 residues. Comparison with several vertebrate sequences shows that it has more in common with the human form than do the forms from common laboratory animals such as rabbits, rats, mice and guinea-pigs.