Knowledge, attitudes and decision-making preferences of men considering participation in the TROG RAVES Prostate Cancer Trial (TROG 08.03)

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• 作者：Stephanie Tesson^a ; Puma Sundaresan^b ; ^c ; ^{purnima.sundaresan@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author} ; ^{purnima.sundaresan@health.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author} ; Brittany Ager^a ; Phyllis Butow^a ; Andrew Kneebone^b ; ^d ; Daniel Costa^e ; Henry Woo^f ; Maria Pearse^g ; Ilona Juraskova^a ; ^h ; Sandra Turner^b ; ^c
• 关键词：Clinical trials ; Radiotherapy ; Informed consent ; Decisional conflict ; Attitudes ; Knowledge
• 刊名：Radiotherapy and Oncology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：119
• 期：1
• 页码：84-90
• 全文大小：405 K

文摘

The RAVES (Trans-Tasman Radiation Oncology Group 08.03) randomised controlled trial (RCT), compares adjuvant radiotherapy with early salvage radiotherapy in men with high risk histopathological features at prostatectomy. The RAVES Decision Aid study evaluates the utility of a decision aid for men considering participation in the RAVES RCT. We report the RAVES Decision Aid study participants’ attitudes and knowledge regarding RCTs, decision-making preferences and decisional-conflict.

Materials and methods

Baseline questionnaires assessed knowledge and attitudes towards RCTs and RAVES RCT. Sociodemographic and clinical predictors of knowledge were examined. Involvement in decision-making and difficulties with the decision-making process were assessed using validated tools.

Results

127 men (median age = 63 years) were recruited through urologists (n = 91) and radiation oncologists (n = 36). Men preferred collaborative (35%) or semi-active (35%) decision-making roles. Most (>75%) felt the RAVES RCT was worthwhile and important with participation being wise. However, nearly half had high decisional-conflict regarding participation. Scores of objective knowledge regarding RCTs and RAVES RCT were low.

Conclusions

Most men with high-risk histopathological features at prostatectomy desire active involvement in decision-making regarding further management. Despite positive attitudes towards RCTs and the RAVES RCT, there were gaps in knowledge and high decisional-conflict surrounding participation.