- 作者：Dan Lundstedt ; Magnus Gustafsson ; Per Malmströ ; m ; Karl-Axel Johansson ; David Alsadius ; Agnetha Sundberg ; Ulrica Wilderä ; ng ; Erik Holmberg ; Harald Anderson ; Gunnar Steineck ; Per Karlsson
- 关键词：Long-term symptoms ; Randomised ; Breast Cancer
- 刊名：Radiotherapy and Oncology
- 出版年：2010
- 出版时间：November 2010
- 年：2010
- 卷：97
- 期：2
- 页码：281-287
- 全文大小：295 K
BackgroundPostoperative radiotherapy decreases the risk for local recurrence and improves overall survival in women with breast cancer. We have limited information on radiotherapy-induced symptoms 10–17 years after therapy.Material and methods
Between 1991 and 1997, women with lymph node-negative breast cancer were randomised in a Swedish multi-institutional trial to breast conserving surgery with or without postoperative radiotherapy. In 2007, 10–17 years after randomisation, the group included 422 recurrence-free women. We collected data with a study-specific questionnaire on eight pre-selected symptom groups.
Results
For six symptom groups (oedema in breast or arm, erysipelas, heart symptoms, lung symptoms, rib fractures, and decreased shoulder mobility) we found similar occurrence in both groups. Excess occurrence after radiotherapy was observed for pain in the breast or in the skin, reported to occur “occasionally” by 38.1 % of survivors having undergone radiotherapy and surgery versus 24.0 % of those with surgery alone (absolute difference 14.1 % ; p = 0.004) and at least once a week by 10.3 % of the radiotherapy group versus 1.7 % (absolute difference 8.6 % ; p = 0.001). Daily life and analgesic use did not differ between the groups.
Conclusions
Ten to 17 years after postoperative radiotherapy 1 in 12 women had weekly pain that could be attributed to radiotherapy. The symptoms did not significantly affect daily life and thus the reduced risk for local recurrence seems to outweigh the risk for long-term symptoms for most women.