Intravitreal Bevacizumab for Symptomatic Retinal Arterial Macroaneurysm

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• 作者：Han Joo ChoAuthor Vitae ; Taek Kwan Rhee ; Hyoung Seok Kim ; Jung Il Han ; Dong Won Lee ; Sung Won Cho ; Jong Woo Kim ; ^{-medical-@hanmail.net}
• 刊名：American Journal of Ophthalmology
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：155
• 期：5
• 页码：898-904.e1
• 全文大小：406 K

文摘

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Purpose

To evaluate the therapeutic effect of intravitreal bevacizumab injection for symptomatic retinal arterial macroaneurysm.

Design

Retrospective interventional case series.

Methods

The study included 23 patients (23 eyes) with symptomatic retinal arterial macroaneurysm. They were categorized according to treatment method into 2 groups: an intravitreal bevacizumab-treated group (11 eyes) and an untreated group (12 eyes). Bevacizumab was injected at the initial visit, followed by as-needed monthly reinjection. Best-corrected visual acuity (BCVA) and central macular thickness were documented and analyzed between groups.

Results

The mean follow-up period for all subjects was 10.83 ¡À 4.6?months. The mean number of injections for the treated group was 1.42 ¡À 0.69. The mean logarithm of the minimal angle of resolution (logMAR) of BCVA improved from baseline at the last follow-up by 0.26 in the bevacizumab-treated group (P?= .02) and by 0.34 in the untreated group (P?= .005). Average central macular thickness decreased from 384.4 ¡À 150.1?¦Ìm to 265 ¡À 112.5?¦Ìm in the bevacizumab-treated group (P?= .0002) and from 413.2 ¡À 155.2?¦Ìm to 236.3 ¡À 103.5?¦Ìm in the untreated group (P?= .008). The BCVA was significantly improved from baseline after 1?month in the bevacizumab-treated group (P?= .02) and after 3?months in the untreated group (P?= .01). However, there was no statistically significant difference in BCVA improvement or central macular thickness improvement achieved at the final visit.

Conclusions

Intravitreal bevacizumab injection likely hastens resolution of macular edema and hemorrhage secondary to retinal arterial macroaneurysm. Intravitreal bevacizumab injection could be an effective treatment option for symptomatic retinal arterial macroaneurysm.