Effect of gamma irradiation on the change of solubility and anti-inflammation activity of chrysin in macrophage cells and LPS-injected endotoxemic mice
详细信息 查看全文
- 作者：Eui-Baek Byuna ; b ; Beom-Su Janga ; b ; Eui-Hong Byunc ; ehbyun80@kongju.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Nak-Yun Sungc ; nysung79@kongju.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMDM ; bone-marrow derived macrophage ; COX ; cyclooxygenase ; ERK ; extracellular signal-regulated kinase ; FITC ; fluorescein isothiocyanate ; HPLC ; high-performance liquid chromatography ; HRP ; horseradish peroxidase ; iNOS ; inducible nitric oxide synthases ; Iκ-B ; inhibitor of κB ; IL ; interleukin ; JNK ; c-Jun N-terminal kinase ; LPS ; lipopolysaccharide ; MAPK ; mitogen-activated protein kinase ; mAb ; monoclonal Ab ; NO ; nitric oxide ; NF-κB ; nuclear factor-κB ; PBS ; phosphate-buffered saline ; PGE2 ; prostagland
- 刊名：Radiation Physics and Chemistry
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：276-285
- 全文大小：1890 K
文摘
- •
Gamma irradiation leads to the structural modification of chrysin.
- •
Gamma irradiation improved the solubility of chrysin.
- •
Gamma-irradiated chrysin significantly inhibited the inflammation mediator.
- •
Anti-inflammation mechanism involved the modulation of MAPKs and NF-κB.
- •
Gamma-irradiated chrysin attenuated the endotoxin-induced lethality.