Afzelin positively regulates melanogenesis through the p38 MAPK pathway
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- 作者：Eunsun Junga ; 1 ; Jin Hee Kimd ; 1 ; Mi Ok Kimb ; Sunghee Jangb ; Mingyeong Kangb ; Sae Woong Ohb ; Youn Hwa Nhoe ; Seung Hyun Kange ; Min Hee Kimf ; See-Hyoung Parkc ; shpark74@hongik.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Jongsung Leeb ; bioneer@skku.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Afzelin ; Melanogenesis ; p38MAPK ; MITF ; TRP-1
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 July 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：167-172
- 全文大小：971 K
文摘
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Afzelin increased melanin content in human melanocytes.
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Afzelin upregulated mRNA levels of MITF, tyrosinase, and TRP-1, but not TRP-2.
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Afzelin led to an activation of p38 MAPK.
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Afzelin regulated melanogenesis by increasing MITF gene expression through activation of the p38 MAPK.