Nickel(II) has growth-inhibiting and apoptosis-activating effects on RPMI-2650 cells.
p53 is involved in arresting damaged cells at G2/M checkpoint and inducing apoptosis.
ROS-mediated mitochondrial damage is a possible mechanism of nickel(II) toxicity.
NAC can help protect against the harmful effects of nickel(II) on the nasal mucosa.