Sorafenib potentiates ABT-737-induced apoptosis in human oral cancer cells

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• 作者：Lee-Han Kim^a ; ¹ ; Ji-Ae Shin^b ; ¹ ; Boonsil Jang^a ; In-Hyoung Yang^a ; Dong-Hoon Won^a ; Joseph H. Jeong^c ; Tae-Ho Chung^d ; Nam-Pyo Cho^a ; Sung-Dae Cho^e ; ^{efiwdsc@gmail.com}
• 关键词：Oral cancer ; ABT-737 ; Sorafenib ; Apoptosis ; Bax ; Bak
• 刊名：Archives of Oral Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：1-6
• 全文大小：1398 K
• 卷排序：73

文摘

Sorafenib synergistically kills oral cancer cells when combined with ABT-737. Combination treatment induces the expression of Bax and Bak and their activation. Inactivation of ERK and STAT3 may be associated with the synergy of combination treatment.