Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein
文摘
MABH improved MPTP-induced movement impairments in mice. MABH prevented dopamine depletion and protected against MPTP-induced dopaminergic neuron damage in mice. MABH increased Nurr1 expression in the SNpc of mice. MABH increased TH, DAT, and VMAT2 expressions by upregulating Nurr1 via phosphorylation of ERK in PC12 cells.