Application of genetically engineered Salmonella typhimurium for interferon-gamma-induced therapy against melanoma

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• 作者：Wonsuck Yoon^a ; Yoo Chang Park^b ; Jinseok Kim^b ; Yang Seok Chae^c ; Jung Hye Byeon^d ; Sang-Hyun Min^e ; Sungha Park^f ; Young Yoo^a ; ^d ; Yong Keun Park^b ; ^{ykpark@korea.ac.kr} ; Byeong Mo Kim^g ; ^{bkim2@yuhs.ac}
• 关键词：Genetically modified Salmonella typhimurium (S. typhimurium) ; Interferon-gamma (IFN-γ) ; SipB160 ; Melanoma ; Treatment option for melanoma
• 刊名：European Journal of Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：70
• 期：Complete
• 页码：48-61
• 全文大小：1190 K
• 卷排序：70

文摘

Salmonella typhimurium expressing SipB160/IFN-γ (S. typhimurium [IFN-γ]) efficiently secreted IFN-γ in cells. S. typhimurium (IFN-γ) invaded the melanoma cells and induced cytotoxicity. S. typhimurium (IFN-γ) inhibited tumour growth in mice bearing B16F10 melanoma in natural killer cell-dependent manner. S. typhimurium (IFN-γ) exerted little toxicity to normal mouse tissues with no observable adverse effects. S. typhimurium (IFN-γ) did not trigger stable anti-tumour immunity but triggered direct tumour cell killing in mouse models.