Cylinder-to-cylinder variation affects multicylinder engine operation and can considerably influence an HCNG engine because fuel composition and excess air ratio differences can contribute to cylinder-to-cylinder variations. In the present study, the effect of the mixer type on cylinder-to-cylinder variation and performance characteristics were investigated using an 11-L heavy-duty CNG engine fuelled with HCNG (CNG 70?vol % , hydrogen 30?vol % ). A change in the mixer type does not affect the characteristics of cylinder-to-cylinder variation and the combustion stability of the HCNG engine. The efficiency of cylinders 1 and 6 is lower than that of the other cylinders because of the configuration of the cylinder in the in-line-type engine. The significant increase in the pressure drop under a wide open-throttle operating condition makes it difficult to satisfy the engine's specifications.