Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives

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• 作者：Dhanya S. Rajalekshmi^a ; ^b ; Farha A. Kabeer^c ; Arya R. Madhusoodhanan^a ; Arun K. Bahulayan^d ; Remani Prathapan^c ; Nisha Prakasan^d ; Sunil Varughese^a ; Mangalam S. Nair^a ; ^b ; ^{msn555in@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cubebin ; Hinokinin ; Amide derivatives ; Anticancer activity ; Morphological analysis ; Apoptosis
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 April 2016
• 年：2016
• 卷：26
• 期：7
• 页码：1767-1771
• 全文大小：1158 K

文摘

(−)-Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a total of 17), with varying functionalities, were tested for their in vitro anticancer activity against six human cancer cell lines (A549, K562, SiHa, KB, HCT116 and HT29) using MTT assay. Cubebin as well as its derivatives containing lactone and amide groups showed significant anticancer activity. In some of the tested cell lines, the amide derivatives showed higher activity. Morphological analysis indicated that these compounds act through apoptosis mediated pathway of cell death and we expect that these results will pave new paths in the development of novel anticancer agents by the derivatization of (−)-cubebin.