Polymorphic properties of micronized mefenamic acid, nabumetone, paracetamol and tolbutamide produced by rapid expansion of supercritical solutions (RESS)
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- 作者：Michael Tü ; rka ; tuerk@kit.edu" class="auth_mail" title="E-mail the corresponding author ; Dennis Boltenb
- 关键词：Supercritical CO2 ; RESS ; Polymorphism ; Mefenamic acid ; Nabumetone ; Paracetamol ; Tolbutamide
- 刊名：The Journal of Supercritical Fluids
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：116
- 期：Complete
- 页码：239-250
- 全文大小：3527 K
文摘
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The RESS process was successfully applied to produce submicron particles of Paracetamol, Mefenamic acid, Nabumetone, and Tolbutamide.
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The mean particle size of processed particles increases in the following order: Mefenamic acid (0.08 μm ≤ x50 ≤ 0.16 μm) < Paracetamol (0.16 μm ≤ x50 ≤ 0.34 μm) < Tolbutamide (0.34 μm ≤ x50 ≤ 0.45 μm) < Nabumetone (0.75 μm ≤ x50 ≤ 0.81 μm).
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This study demonstrates that under certain temperature (333 and 353 K) and pressure (15, 20, 25 and 30 MPa) conditions RESS enables the formation of the favorable Tolbutamide polymorphic form II.
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Simple static treatment with supercritical CO2 does not induce polymorphic conversion of the drugs investigated.