Production and stabilization of olanzapine nanoparticles by rapid expansion of supercritical solutions (RESS)
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- 作者：Maria C. Paisanaa ; Katrin C. Mü ; llersb ; Martin A. Wahlb ; Joã ; o F. Pintoa ; jfpinto@ff.ul.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：HPMC ; hydroxypropylmethylcellulose ; DSC ; differential scanning calorimetry ; FTIR ; Fourier transform infrared ; OLZ ; olanzapine ; PEG ; polyethylene glycol ; PM ; physical mixture ; Psb ; polysorbate 80 ; PSD ; particle size distribution ; RESS ; rapid expansion of supercritical solutions ; RESSAS ; rapid expansion of supercritical solutions into aqueous solution ; RESOLV ; rapid expansion of supercritical solutions into liquid solvent ; scCO2 ; carbon dioxide in supercritical state ; SLS ; sodium lauryl sulfate
- 刊名：The Journal of Supercritical Fluids
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：124-133
- 全文大小：2478 K
文摘
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A drug poorly soluble in water was nanosized (150–350 nm).
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Successful production of olanzapine nanosuspensions was achieved by RESSAS.
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The rate of OLZ dissolution was increased significantly when processed by RESSAS.
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Steric hindrance or electrostatic stabilization promoted the stability of the suspension.