Production of theophylline nanoparticles using rapid expansion of supercritical solutions with a solid cosolvent (RESS-SC) technique
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- 作者：Hirohisa Uchidaa ; uchida@shinshu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masamichi Nishijimaa ; Kyohei Sanoa ; Kohei Demotoa ; Junichi Sakabeb ; Yusuke Shimoyamab
- 关键词：RESS-SC ; Nanoparticle ; Supercritical carbon dioxide ; Theophylline ; Solid cosolvents ; Particle collection conditions effects
- 刊名：The Journal of Supercritical Fluids
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：105
- 期：Complete
- 页码：128-135
- 全文大小：4174 K
文摘
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The production of theophylline nanoparticles by RESS-SC was examined.
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The availability of l-menthol or vanillin as a solid cosolvent was examined.
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l-Menthol was unsuitable for a solid cosolvent in the present conditions.
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Theophylline nanoparticles were obtained by use of vanillin as a solid cosolvent.
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Particle collection conditions have negligible effects on the particle sizes.