Manipulation of environmental oxygen modifies reactive oxygen and nitrogen species generation during myogenesis
详细信息 查看全文
- 作者：Rachel McCormick ; Timothy Pearson1 ; Aphrodite Vasilaki ; vasilaki@liverpool.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：CuZnSOD ; copper ; zinc superoxide dismutase ; MnSOD ; manganese superoxide dismutase ; mpc's ; myogenic precursor cells ; NFκB ; nuclear transcription factor κappa B ; NO ; nitric oxide ; ROS ; reactive oxygen species ; RONS ; reactive oxygen and nitrogen species ; SOD ; superoxide dismutase ; SOD1 ; copper ; zinc superoxide dismutase ; WT ; wild type ; H2O2 ; hydrogen peroxide
- 刊名：Redox Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：8
- 期：Complete
- 页码：243-251
- 全文大小：2012 K
文摘
- •
Environmental O2 concentrations were found to influence myogenesis in vitro.
- •
Proliferation of primary muscle cells was increased when cells were grown in 6% O2.
- •
Cells grown in 20% O2 showed increased RONS formation compared with cells in 6% O2.
- •
Cells grown in 20% O2 had higher antioxidant defence enzyme contents.
- •
These data suggest that RONS generated at 20% O2 may limit myogenesis in vitro.