NADPH oxidase (NOX) 1 mediates cigarette smoke-induced superoxide generation in rat vascular smooth muscle cells

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• 作者：Kyung-Hwa Chang^a ; Jung-Min Park^a ; Chang Hoon Lee^a ; Bumseok Kim^b ; Kyung-Chul Choi^c ; Seong-Jin Choi^d ; Kyuhong Lee^d ; Moo-Yeol Lee^a ; ^{mlee@dongguk.edu}
• 关键词：Cigarette smoke ; NADPH oxidase (NOX) ; Vascular smooth muscle cells (VSMC) ; Superoxide ; Cigarette smoke extract (CSE) ; Total particulate matter (TPM)
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：38
• 期：Complete
• 页码：49-58
• 全文大小：985 K
• 卷排序：38

文摘

ROS probes should be used with caution as CS may interfere with the characteristic optical signals of probes. CS generates superoxide by stimulating cells to produce superoxide and by producing superoxide directly in the aqueous medium. NOX, specifically NOX1 is mainly responsible for CS-induced superoxide production in VSMC. Superoxide generated by NOX contributes to the cytotoxicity of CSE.